Predictions for each Week 6 game are broken into three sections: Top 25 teams, best games between unranked teams and the rest of the slate. The South Dakota State Jackrabbits and North Dakota State Bison face off on Sunday in the college football. ET: UMass 28, UConn 14, Duke at Boston College, 7 p.m. I think this Yellow Jacket team can rally behind him and give him his second win, this time at home. Without fail, there's one game every week in these predictions that I just stare at for 10-15 minutes before accepting that I have no clue what to expect. NFL expert picks, predictions, lines for Week 2 highlighted by the Los Angeles Chargers vs Kansas City, Miami at Baltimore, and Minnesota at Philadelphia. The Week 8 slate begins on Wednesday night with Appalachian . Kansas will play host to College GameDay for the first time in program history as it attempts to go to 6-0 . ET, ABC), No. Utah -3 (-110) 1-unit. No. Last year, Oklahoma came from behind from a 28-7 first-quarter deficit to win 55-48 in a thriller. LSU needs Jaylon Daniels to play his best game of the season to keep pace with a Tennessee offense that averages 559.3 total yards and 48.5 points per game. The Horned Frogs handed Oklahoma its second straight loss last week, winning 55-24 in a game that wasn't all that close from the start. One of the biggest stories of this season has been high-scoring offenses, which is a common story for teams in the Top 10. ET: Georgia Southern 24, South Alabama 16, FIU at North Texas, 4 p.m. Week 6 doesn't feature a ton of big games, but there are a number of fun matchups on the slate. While the story of the Illinois season has been centered around Brown, the defense has been elite. ET: The latest in the sports world, emailed daily. The good news for the Kansas offense is that TCU's defense has been gashed a bit by SMU and Oklahoma in the last two weeks. But the combination of Arizona State's above-average secondary and Stanford's considerably-below-average run defense should keep another upset from happening. Let's start with a quick recap of Week 7 of NCAAF, as there were major shifts in the power . It's just not the best matchup on the schedule. Clemson looks like the clear ACC favorite, coming off of a statement 20-10 win over NC State at home. No. And though Tanner McKee has 10 touchdowns against zero interceptions since becoming Stanford's starting quarterback, this will be the toughest defense he has faced by a wide margin. It was my first . 15 Texas A&M, No. Last year's game necessitated four overtimes before Oklahoma won 53-45, which, somewhat fittingly, was the widest margin of victory since 2013excluding the 2018 Big 12 championship. ET, ESPN+), Auburn at No. Luckily for Georgia, the Dawgs play at home against an Auburn team that is struggling. This one should be close throughout, and the Bruins might have a slight advantage in taking this one at home. Saturday will mark just the fourth overall meeting between these two. Aside from USC, UCLA is the last remaining undefeated team in the Pac-12. It's unclear if either QB will suit up Saturday. Michigan State at No. Prediction: Ohio State 56, Michigan State 13. *Can Florida State's offensive line hold up? The Bulls are 1-4, with their only win coming against MEAC opponent Howard earlier in the season. Predictions for each Week 6 game are broken into three sections: Top 25 teams, best games between unranked teams and the rest of the slate. Prediction:San Diego State 41, New Mexico 13, No. Up next for the Terps? ET: Ohio 35, Akron 13, Georgia Southern at Georgia State, 2 p.m. 3 Iowa. Penn State is undefeated, but the Nittany Lions have yet to play a ranked team yet on their schedule. Or earlier this season when Fresno State toppled UCLA before just barely surviving at home against winless UNLV? ET, East Carolina (3-2) at UCF (2-2), 6 p.m. With Adrian Martinez playing as well as he has been over the past five weeks, this is going to be the stiffest resistance Michigan's defense has faced thus far. Head coach Mike Norvell and the Seminoles headed into the 2022 season with their backs against the wall. The Wildcats are 3-2 on the season, and looking like they could finish with their first season at .500 since 2017. Both of these teams are undefeated, and Kansas is 5-0 for the first time since 2009. The Kansas defense is capable of getting a few stops against Max Duggan and the TCU offense. 17 North Carolina at Virginia, Noon ET. ET, CBS), No. Even if the Chants decide to be nice and focus primarily on running the ball (and the clock), you're still talking about an offense that averages 6.4 yards per carry against a defense that just allowed 503 rushing yards in a 59-33 loss to Georgia Southern. AZ/CO/CT/IL/IN/IA/LA/MI/NH/NJ/NY/OR/PA/TN/VA/WV/WY only. 17 Iowa. Daniels may be able to put Kansas back on track when he's available, since he's eyeing a return this season. 18 Auburn (4-1), 3:30 p.m. No. Arizona State is searching for its next head coach, while UCLA is back near the top of the college football world. No. He doesn't put up fancy numbers or many Heisman-level performances, but the Wolverines live through their success on the ground, and a team like Rutgers won't have an answer for that. 21 Minnesota 20-10. Week 6 of college football looks to continue a chaotic season filled with upsets and surprises. Quarterback Quinn Ewers had a frightful performance against the Cowboys, but Texas had a chance to regroup. 17 Ole Miss (3-1), Noon ET. But through five weeks of the season, this matchup has lost a lot of its luster. Clemson has had two close bouts against Syracuse and Florida State in their last two games. Georgia will win this year's College Football Playoff Championship. ET (Friday)Charlotte 28-21, West Virginia (2-3) at Baylor (4-1), Noon ETBaylor 24-17, South Carolina (3-2) at Tennessee (3-2), Noon ETTennessee 35-20, Akron (1-4) at Bowling Green (2-3), Noon ETBowling Green 28-14, Northern Illinois (3-2) at Toledo (3-2), Noon ETToledo 31-17, Georgia Tech (2-3) at Duke (3-2), 12:30 p.m. ETGeorgia Tech 31-27, Old Dominion (1-4) at Marshall (2-3), 2 p.m. ETMarshall 42-13, Florida State (1-4) at North Carolina (3-2), 3:30 p.m. ETNorth Carolina 45-21, Wisconsin (1-3) at Illinois (2-4), 3:30 p.m. ETWisconsin 24-17, Central Michigan (2-3) at Ohio (1-4), 3:30 p.m. ETOhio 28-27, Miami-Ohio (2-3) at Eastern Michigan (3-2), 3:30 p.m. ETEastern Michigan 35-24, Ball State (2-3) at Western Michigan (4-1), 3:30 p.m. ETWestern Michigan 35-24, Middle Tennessee (2-3) at Liberty (4-1), 3:30 p.m. ETLiberty 34-20, San Jose State (3-2) at Colorado State (1-3), 3:30 p.m. ETSan Jose State 27-23, Florida Atlantic (3-2) at UAB (3-2), 3:30 p.m. ETUAB 28-17, North Texas (1-3) at Missouri (2-3), 4 p.m. ETMissouri 45-21, East Carolina (3-2) at UCF (2-2), 6 p.m. ETUCF 35-31, UTSA (5-0) at Western Kentucky (1-3), 7 p.m. ETUTSA 34-31, Georgia Southern (2-3) at Troy (2-3), 7 p.m. ETGeorgia Southern 28-24, Buffalo (2-3) at Kent State (2-3), 7 p.m. ETBuffalo 31-27, South Alabama (3-1) at Texas State (1-3), 7 p.m. ETSouth Alabama 28-21, UTEP (4-1) at Southern Miss (1-4), 7 p.m. ETUTEP 24-21, Georgia State (1-4) at Louisiana-Monroe (2-2), 8 p.m. ETGeorgia State 27-20, Memphis (3-2) at Tulsa (1-4), 9 p.m. ETTulsa 35-28, New Mexico State (1-5) at Nevada (3-1), 10:30 p.m. ETNevada 45-10, UCLA (3-2) at Arizona (0-4), 10:30 p.m. ETUCLA 31-21. The Hogs will dominate the time-of-possession battle and escape with a narrow victory. Statistically Generated Predictions for all Week 6 Matchups. That streak will continue this weekend when Indiana is unable to find any yards on the ground and has trouble scoring. Multiple teams from the conference are in the running for the top four after the initial CFP rankings release, as are usual challengers Ohio State, Clemson and Michigan. 3 Penn State 24-23 on a last-second field goal. Cincy's offense, which ranks 18th nationally in scoring (40.2 ppg), should have no problems against a USF defense that is tied at 122nd in scoring defense. CFB PICKS. 3 Ohio State (-25.5) at Michigan State (4 p.m. It might be time to embrace the possibility that Nebraska is the second-best team in the Big Ten West. ET: Houston 32, SMU 26, Auburn at Mississippi State, 7:30 p.m. Meanwhile, Michigan's once-dominant rushing attack has tapered off considerably as of late, held below 3.0 yards per carry by both Rutgers and Wisconsin. Enjoy the free college football picks against the spread as well! The Rebels only had one gain of 20 or more yards, and that 42-yard pass to Chase Rogers didn't come until the fourth quarter when the game was effectively over. Nov 22, 2022 9:36 AM EST. The Ducks will head to Buffaloes territory and pummel Colorado on the road. 19 Kansas vs. No. All Top 25 games Saturday unless otherwise noted. Oregon is a 13-point favorite on the road, and the Ducks offense will likely be too much for this Arizona defense. ET. Oklahoma State hosts Texas Tech, and Kansas State visits Iowa State on the same day. All signs are pointing to another Michigan-Ohio State game to decide the Big Ten East this season. Washington looked like one of the best teams in the Pac-12, until UCLA defeated the Huskies 40-32 last Friday night. ET. The Bulldogs lost 31-16 to LSU in Week 3, so this game doesn't have a ton of SEC West implications, with Alabama leading the pack. If the turnover margin in this one ends up being a wash, I like Penn State to get the road win, as I have substantially more faith in the Nittany Lions offense in a battle of field position. ET. ET. I think this one will be close for awhile before Tennessee pulls away in the fourth. ET, UTSA (5-0) at Western Kentucky (1-3), 7 p.m. And it definitely feels like they have no hope of keeping pace with an Alabama team that has now scored at least 31 points in 31 consecutive games. James Madison at Arkansas State, 7 p.m. Longhorns QB Quinn Ewers was injured in the first quarter against Alabama on Sept. 10, and he hasn't seen the field since. Headlines have been swirling around both these teams for the past few months, and many of them haven't been favorable. The Tar Heels are steamrolling through the ACC, with four straight conference wins. My official position for this week is that only two of the 14 games pitting a ranked team against an unranked opponent will result in an upset, though I do anticipate a few others being way too close for comfort for the favorites. Week 6. 20 Florida (3-2) vs. Vanderbilt (2-3), Noon ET. Just being ranked in Week 6 is a major achievement for the program's new head coach and his rebuilding of the team. Miami quarterback Tyler Van Dyke entered 2022 with plenty of offseason hype, but he hasn't performed as well as expected early in the year. 4 Penn State vs. No. The Beavers are 6-2, with their only downfalls coming against Utah and USC. 14 NC State (-3) (8 p.m. Penn State won't be a riser after a win against Indiana, unless it demolishes the Hoosiers on the road. The Orange have decent wins against Purdue and Louisville, but the formula for stopping them has become clear. Top college football predictions for Week 6. Let's get back on the right track. While the spotlight has been pointed toward the offense, Tulane's defense has allowed only 17.4 points per game. Circa Sports reopened its conference future odds ahead of Week 6 with six different ACC teams at 8-to-1 or less to win the title Clemson at +180 (risking $1 to win 41.80), Pittsburgh at +470 . ET: Pitt 28, VT 20, East Carolina at Tulane, 3:30 p.m. Alabama has won this game by at least 18 points in six of the last seven seasons, though it is at least noteworthy that the exception to that rulea 27-19 game at Texas A&M in 2017was the lone instance during that stretch in which the Aggies were unranked. In four games against FBS opponents, Syracuse has thrown for a total of 510 yards and one touchdown. No. No. This should also give the ACC's rushing leader, running back Sean Tucker, time to rest uphe got banged up during Syracuse's blowout win over Wagner. 6 Oklahoma (5-0) vs. No. In three games against Power Five opponents, the Tigers have tallied 77 carries for 145 yards with no touchdowns. We will have 6 Premium Picks against the spread this week! 2 Georgia vs. No. The Eagles have struggled so far this season, losing to Rutgers to open the year before dropping two out of its last four against Virginia Tech and Florida State. They won't all be this easy for SDSU, but its first Mountain West Conference win of the season will be a blowout. This week will show just how good the SEC is, and just how underrated the Big 12 is, with incredible conference games on deck. North Carolina is averaging 41.8 points on the season, but its defense has barely been able to stop anyone. Jay Biggerstaff/Getty Images, Watch more top videos, highlights, and B/R original content, Dorian Thompson-Robinson. Select A Week 6 Matchup: Thursday, October 7th - Houston Vs Tulane. It's been an up-and-down road for the Tigers, but they've had back-to-back weeks scoring more than 40 points against SEC opponents. The Trojans are 13-point favorites against Washington State at home. NCAA football predictions and Week 6 Opening Line Report with Best Bets and Picks by expert college football handicappers at Docsports.com. No. ET: San Jos State 17, Colorado State 10, Hawai'i at Fresno State, 10:30 p.m. ET: Tulane 30, ECU 27, Tulsa at Navy, 3:30 p.m. ET See No. 17 TCU, Noon ETSee No. The 2022 College Football Week 6 will feature Tennessee Vs LSU and Texas Tech Vs Oklahoma St. We will have 6 more Premium Picks against the spread this week! TCU's defense is 65th nationally, and Kansas' is 79th, so this could potentially be a shootout. One of the college picks the model is high on in Week 9: No. Michigan has a new look and confidence to them behind quarterback J.J. McCarthy. No. And though the preseason Heisman favorite hasn't been anywhere near as proficient as expected, we've got to go with Spencer Rattler over Casey Thompson if this boils down to which quarterback has the most fourth-quarter heroics up his sleeve. ET, Old Dominion (1-4) at Marshall (2-3), 2 p.m. ET: Coastal Carolina at UL Monroe, 8 p.m. But here's hoping you're enjoying the analysis/commentary more than you'd enjoy watching a coin flip 112 times. Freshman running back Quinshon Judkins has been sensational this season, accounting for 535 yards and six touchdowns so far. It is allowing just 8.9 points and 75.6 yards on the ground. ET. 11 Michigan State (5-0) at Rutgers (3-2), Noon ET. The Pac-12 matchup features the 6-2 Utah squad, which has faired well in conference play with a 4-1 record. Folks, we are in for a fun matchup on Saturday. 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