Yamini, S., West, K. P., Jr., Wu, L., Dreyfuss, M. L., Yang, D. X., and Khatry, S. K. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. Junghans, A., Sies, H., and Stahl, W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Antioxidant status and neovascular age-related macular degeneration. View abstract. Spread supplemented with moderate doses of vitamin E and carotenoids reduces lipid peroxidation in healthy, nonsmoking adults. View abstract. A. Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer. BMC Ophthalmol 2007;7:3. 2010;21(6):544-549. Hajizadeh-Sharafabad F, Tarighat-Esfanjani A, Ghoreishi Z, Sarreshtedari M. Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: effects on anthropometric indices, body composition and metabolic parameters. 80 mg of zinc. 2014;52(4):198-205. Ophthalmologica 2017;237(3):159-66. Clin.Nutr. 2000;41(11):3322-3326. View abstract. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. View abstract. Hammond BR Jr, Wooten BR, Snodderly DM, et al. Previous studies have found that lutein helps bolster the skins natural antioxidant system and protect against sun damage, and reduces the risk of age-related Am J Clin Nutr 1999;70:509-16. Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. The recommended lutein dosage for preventing oxidative damage and lowering symptoms of eye or skin disorders isbetween 6 milligrams and 30 milligrams daily for adults, according to the American Macular Degeneration Association. It contains 20 mg of lutein, 4 mg of zeaxanthin, 408mg of vitamin C, 242.3mg of vitamin E, 30mg of zinc, and 1.5mg of copper. 2012;53(10):6178-6186. View abstract. A 2009 study conducted on diabetic rats found that supplementing with lutein and DHA (a crucial type of omega-3 fatty acid) helped normalize all diabetes-induced biochemical modifications. Keep in mind that as with other antioxidants, people seem to differ in terms of how capable their bodies are of absorbing lutein. Invest Ophthalmol Vis Sci. 2001;119(7):1009-1019. Ros, M. M., Bueno-de-Mesquita, H. B., Kampman, E., Aben, K. K., Buchner, F. L., Jansen, E. H., van Gils, C. H., Egevad, L., Overvad, K., Tjonneland, A., Roswall, N., Boutron-Ruault, M. C., Kvaskoff, M., Perquier, F., Kaaks, R., Chang-Claude, J., Weikert, S., Boeing, H., Trichopoulou, A., Lagiou, P., Dilis, V., Palli, D., Pala, V., Sacerdote, C., Tumino, R., Panico, S., Peeters, P. H., Gram, I. T., Skeie, G., Huerta, J. M., Barricarte, A., Quiros, J. R., Sanchez, M. J., Buckland, G., Larranaga, N., Ehrnstrom, R., Wallstrom, P., Ljungberg, B., Hallmans, G., Key, T. J., Allen, N. E., Khaw, K. T., Wareham, N., Brennan, P., Riboli, E., and Kiemeney, L. A. Seddon JM, Ajani UA, Sperduto R, et al. Roodenburg AJ, Leenen R, van het Hof KH, et al. Cancer Epidemiol.Biomarkers Prev. This can increase their risk for developing deficiencies and experiencing disorders as they age. Cancer Epidemiol.Biomarkers Prev. Retina 2008;28(1):103-110. Nutr Cancer 1998;32(3):154-158. View abstract. Sabour-Pickett, S., Nolan, J. M., Loughman, J., and Beatty, S. A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. Likely not, but overall we still have a way to go when it comes to understanding the full potential of lutein in terms of disease prevention, bioavailability, metabolism and dose-response relationships. Diet and lifestyle correlates of lutein in the blood and diet. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. View abstract. View abstract. Am.J.Clin.Nutr. View abstract. 2006;90(7):927-928. Ophthalmology 2012;119(11):2282-2289. Berendschot, T. T., Broekmans, W. M., Klopping-Ketelaars, I. 2001;55(4):252-259. Heinrich, U., Gartner, C., Wiebusch, M., Eichler, O., Sies, H., Tronnier, H., and Stahl, W. Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. Its possible that for some people, even with a relatively high intake of high-antioxidantfoods, their blood levels might be high enough in nutrients like lutein, but testing tissues within their eyes will show that their retinal levels still remain too low. Moeller, S. M., Voland, R., Tinker, L., Blodi, B. 1999;19(6):491-495. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Schupp C, Olano-Martin E, Gerth C, et al. WebThe B Vitamins are essential in improving skin conditions such as eczema. View abstract. 2014 Jan 22;6(1):452-65. Xiong K, Zhao Y, Hu S, Ma A, Ma Y. Dose-response relationship between oral lutein intake and plasma lutein concentration: A randomized controlled trial. View abstract. Photochem.Photobiol. Retina 1981;1(4):296-310. Am J Clin Nutr 1995;62:604-10. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Bone, R. A., Landrum, J. T., Guerra, L. H., and Ruiz, C. A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. Am J Clin Nutr 2006;83(1):163-169. Snellen, E. L., Verbeek, A. L., Van Den Hoogen, G. W., Cruysberg, J. R., and Hoyng, C. B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. Am J Clin Nutr 2003;78(5):985-992. Arch Neurol 2000;57:956-63. Falsini, B., Piccardi, M., Iarossi, G., Fadda, A., Merendino, E., and Valentini, P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. . Since the plant It occurs in certain algae and causes the pink-red color in salmon. Int.J.Vitam.Nutr.Res. Calories 9.6 kcal Protein 0.51 g Fat 0.75 g Carbohydrate 0.24 g Sodium 00.012 g Lutein 18.0 mg Zeaxanthin 3.6 mg -cryptoxanthin 28.8 g -carotene 1080 g -carotene 270 g Lycopene 2.1 mg Bilberry extract 30.0 mg Blackcurrant extract 72.0 mg DHA 50.9 mg Vitamin B1 0.9 mg Its recommended that you take lutein supplements along with meals because this carotenoid acts like a fat-soluble nutrient and is absorbed better when eaten with. Med.Sci.Sports Exerc. 2007;125(9):1225-1232. 2004;80(1):131-136. Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. The first 200 years. Chew, E. Y., Clemons, T., SanGiovanni, J. P., Danis, R., Domalpally, A., McBee, W., Sperduto, R., and Ferris, F. L. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). 2012;96(5):1207S-1213S. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. View abstract. Herron, K. L., McGrane, M. M., Waters, D., Lofgren, I. E., Clark, R. M., Ordovas, J. M., and Fernandez, M. L. The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs. Hammond BR Jr, Johnson EJ, Russell RM, et al. Ravindran, R. D., Vashist, P., Gupta, S. K., Young, I. S., Maraini, G., Camparini, M., Jayanthi, R., John, N., Fitzpatrick, K. E., Chakravarthy, U., Ravilla, T. D., and Fletcher, A. E. Inverse association of vitamin C with cataract in older people in India. 2012;96(5):1223S-1233S. Incidence of cataract operations in Finnish male smokers unaffected by alpha tocopherol or beta carotene supplements. Luckily, doctors now have the ability to measure macular pigment levels of lutein in someones eyes in order to determine if that person is at an increased risk for disease. Long-term nutrient intake and early age-related nuclear lens opacities. van der Horst-Graat JM, Kok, F. J., and Schouten, E. G. Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people. View abstract. Lai JS, Veetil VO, Lanca C, et al. Cancer Epidemiol.Biomarkers Prev. B. Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. Dietary lutein and cognitive function in adults: A meta-analysis of randomized controlled trials. Chen F, Hu J, Liu P, Li J, Wei Z, Liu P. Carotenoid intake and risk of non-Hodgkin lymphoma: a systematic review and dose-response meta-analysis of observational studies. Spraycar M, ed. 2012;32(6):418-424. Zuniga KE, Bishop NJ, Turner AS. A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract. Vitamin A and carotenoids and the risk of Parkinson's disease: a systematic review and meta-analysis. It may help decrease heart problems. 2005 - 2023 WebMD LLC. View abstract. View abstract. A., Fisher, A. I., Klein, R., Palta, M., Block, G., Millen, A. E., and Wright, J. D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Natarajan, L., Rock, C. L., Major, J. M., Thomson, C. A., Caan, B. J., Flatt, S. W., Chilton, J. The risk of vision loss decreased by 19%. View abstract. J.Nutr.Sci.Vitaminol. WebLutein is a nutrient best known for its help maintaining eye health, though it may have other health benefits as well. View abstract. 2014;42(1):25-38. 2011;24 Suppl 1:147-150. View abstract. Vision Res. Am.J.Clin.Nutr. Epidemiology 2004;15(6):738-745. Yeum, K. J., Booth, S. L., Sadowski, J. Curr.Eye Res. Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007-2012. 2012;56(1):126-146. J Aging Res 2019;2019:3709402. 2000;46(11):1818-1829. Optometry 2000;71:147-64.. View abstract. Coll.Antropol. 2002;75(5):503-506. View abstract. View abstract. View abstract. In the process, antioxidants like lutein protect healthy cells while halting the growth of malignant cells. View abstract. Exp.Gerontol. Murray, I. J., Makridaki, M., van der Veen, R. L., Carden, D., Parry, N. R., and Berendschot, T. T. Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLEAR study. VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. View abstract. Dwyer, J. H., Paul-Labrador, M. J., Fan, J., Shircore, A. M., Merz, C. N., and Dwyer, K. M. Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles Atherosclerosis Study. Serum antioxidants and age-related macular degeneration in a population-based case-control study. View abstract. This includes a 2018 study in which researchers concluded: Dietary lutein supplementation may be a promising alternative and/or adjunct therapeutic candidate against breast cancer.. Invest Ophthalmol.Vis.Sci. Mol.Nutr.Food Res. Eye Disease Case-Control Study Group. 1996;126(9):2098-2106. View abstract. Therapeutic effect of lutein supplement on non-proliferative diabetic retinopathy: a retrospective study. Some observational studies show that xanthophyll carotenoids, including lutein, can help reduce the risk of developing heart disease and stroke. Foods View abstract. Br J Nutr 2021;126(7):1028-1039. View abstract. View abstract. JAMA Ophthalmol 2022. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. View abstract. Plant foods and colon cancer: an assessment of specific foods and their related nutrients (United States). Acta Ophthalmol. According to the Centers for Disease Control and Prevention (CDC), Americans get American Macular Degeneration Association, Top 7 Ways Carrot & Carrot Juice Benefit Your Body, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Is Lamb Healthy? That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. Ophthalmology 2008;115:324-33. Ophthalmic Res. Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Mnnist S, Yaun SS, Hunter DJ, et al. Effects of Lutein/Zeaxanthin Supplementation on the Cognitive Function of Community Dwelling Older Adults: A Randomized, Double-Masked, Placebo-Controlled Trial. Garca-Layana A, Recalde S, Alamn AS, Robredo PF. View abstract. Skin Pharmacol.Physiol 2007;20(4):199-210. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. 2000;41(5):1200-1209. 1999;70(2):247-251. View abstract. Tan, J. S., Wang, J. J., Flood, V., Rochtchina, E., Smith, W., and Mitchell, P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Bone, R. A., Landrum, J. T., Mayne, S. T., Gomez, C. M., Tibor, S. E., and Twaroska, E. E. Macular pigment in donor eyes with and without AMD: a case-control study. This carotenoid is obtained from both foods and supplements, which are generally considered safe. A., de Vries, A. J., Goldbohm, R. A., Tijburg, L. B., Kardinaal, A. F., and van Poppel, G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Arch.Ophthalmol. Together they can help to preserve vision by protecting the eyes from oxidative stress and UV light damage. Dreher, M. L. Pistachio nuts: composition and potential health benefits. Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. View abstract. View abstract. JAMA 1994;272:1413-20. Nutr.J. View abstract. Weigert, G., Kaya, S., Pemp, B., Sacu, S., Lasta, M., Werkmeister, R. M., Dragostinoff, N., Simader, C., Garhofer, G., Schmidt-Erfurth, U., and Schmetterer, L. Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration. Siems, W. G., Sommerburg, O., and van Kuijk, F. J. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. View abstract. View abstract. 2007;16(10):2008-2015. Sommerburg, O. G., Siems, W. G., Hurst, J. S., Lewis, J. W., Kliger, D. S., and van Kuijk, F. J. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Goodman GE, Schaffer S, Omenn GS, et al. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. In addition, reduced Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A. Arch.Ophthalmol. However, most studies show that benefits are greatest when someone consumes 10 milligrams of lutein per day or more (along with about two milligrams of zeaxanthin perday). View abstract. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. 1998;7(6):537-544. Am J Clin Nutr 1998;68:82-9. View abstract. Am.J.Clin.Nutr. Kobayashi J, Tominaga E, Ozeki M, Okubo T, Nakagawa K, Miyazawa T. Randomized controlled trial of a water-soluble formulation of lutein in humans. Exp Eye Res. View abstract. Lutein and its relative zeaxanthin are pigments called carotenoids. The ARIC Study Investigators. Age-Related Eye Disease Study 2 Research Group. Shao, A. and Hathcock, J. N. Risk assessment for the carotenoids lutein and lycopene. When we eat foods high in lutein or take it in supplement form, its believed to be pretty easily transported around the body, especially to the parts of the eyes called the macula and the lens. Goodman, M. T., Kiviat, N., McDuffie, K., Hankin, J. H., Hernandez, B., Wilkens, L. R., Franke, A., Kuypers, J., Kolonel, L. N., Nakamura, J., Ing, G., Branch, B., Bertram, C. C., Kamemoto, L., Sharma, S., and Killeen, J. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis. Appl.Ergon. View abstract. Ophthalmology 2003;110(1):51-60. Eur.J Clin.Nutr. Nutrients. Eliassen, A. H., Hendrickson, S. J., Brinton, L. A., Buring, J. E., Campos, H., Dai, Q., Dorgan, J. F., Franke, A. View abstract. View abstract. 2010;93(5):300-308. Molecules. 1995;36(12):2531-2541. Nutr Neurosci 2021. View abstract. View abstract. View abstract. Lutein protects the eyes by filtering out a percentage of damaging short-wavelength UV light that negatively affects delicate parts of the eyes, such asthe retina (the macula). Cho E, Seddon JM, Rosner B, et al. Am J Clin Nutr 1999;70:517-24. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. View abstract. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. WebLutein & Zeaxanthin Eye Health Supplement for Adults - Delicious Vegan Eye Vitamins Lutein and Zeaxanthin Gummies - Zeaxanthin Plus Lutein 20mg for Vision Clarity Dry Eye Relief and Blue Light Support. View abstract. 2012;53(12):7871-7880. 2009;102(2):186-190. Mol.Nutr.Food Res. View abstract. Richer, S., Devenport, J., and Lang, J. C. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. 2002;80(4):368-371. View abstract. View abstract. Furosemide: 2 people, View abstract. SanGiovanni, J. P. and Neuringer, M. The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field. Olmedilla, B., Granado, F., Blanco, I., and Vaquero, M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Bloomer RJ, Fry A, Schilling B, Chiu L, et al. View abstract. People who dont eat many vegetable or fruits can probably benefit from supplementing with higher doses, as can older adults, smokers and post-menopausal women. O'Neill, M. E., Carroll, Y., Corridan, B., Olmedilla, B., Granado, F., Blanco, I., van den, Berg H., Hininger, I., Rousell, A. M., Chopra, M., Southon, S., and Thurnham, D. I. 7-15-2001;391(2):160-164. Asia Pac J Clin Nutr 2017;26(3):406-11. Handelman, G. J., Nightingale, Z. D., Lichtenstein, A. H., Schaefer, E. J., and Blumberg, J. van den Berg H. Effect of lutein on beta-carotene absorption and cleavage. PLoS One 2019;14(12):e0227048. Ito, Y., Wakai, K., Suzuki, K., Ozasa, K., Watanabe, Y., Seki, N., Ando, M., Nishino, Y., Kondo, T., Ohno, Y., and Tamakoshi, A. The human body cannot synthesize lutein or zeaxanthin on its own, which means we must obtain these important nutrients from our diets (or, in some cases, supplements). 60 Count (Pack of 1) 4.5 4.5 out of 5 View abstract. A. Ito, Y., Wakai, K., Suzuki, K., Tamakoshi, A., Seki, N., Ando, M., Nishino, Y., Kondo, T., Watanabe, Y., Ozasa, K., and Ohno, Y. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. Steinmetz KA, Potter JD. Am J Clin Nutr 2004;79 1045-52. View abstract. Are supplements really necessary to achieve benefits? 1997;6(8):617-623. Clin.Chem. A., Snodderly, D. M., Klein, M. L., Wooten, B. R., and Chappell, R. Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. Koh HH, Murray IJ, Nolan D, et al. Zinc is an important mineral that plays a key role in skin health (17). J Nutr 1997;127:1636S-45S. 2003;44(6):2461-2465. View abstract. View abstract. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli, Brussels sprouts, eggs, oranges, and papaya. According to some animal studies, higher levels of carotenoids within the blood are linked with fewer problems controlling blood sugar and a lower risk for diabetesor related complications. 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